Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia
Identifieur interne : 000A20 ( Main/Exploration ); précédent : 000A19; suivant : 000A21Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia
Auteurs : Mohammad Khalid ; Basha Khan ; Fahad Al Rabiah ; Ruwaida Alismaili ; Sarfraz Saleemi ; Agha Muhammad Rehan-Khaliq ; Ihab Weheba ; Hail Al Abdely ; Magid Halim ; Quaid Johar Nadri ; Abdullah Mohsin Al Dalaan ; Mohamed Zeitouni ; Taimur Butt ; Eid Al MutairySource :
- Annals of Saudi Medicine [ 0256-4947 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Adulte d'âge moyen, Antiviraux (usage thérapeutique), Arabie saoudite (épidémiologie), Association de médicaments, Centres de soins tertiaires, Coronavirus du syndrome respiratoire du Moyen-Orient, Délai jusqu'au traitement, Femelle, Humains, Infections asymptomatiques, Infections à coronavirus (diagnostic), Infections à coronavirus (traitement médicamenteux), Insuffisance respiratoire (virologie), Interféron alpha (usage thérapeutique), Mâle, Pneumopathie infectieuse (virologie), Polyéthylène glycols (usage thérapeutique), Protéines recombinantes (usage thérapeutique), Retard de diagnostic, Ribavirine (usage thérapeutique), Sujet âgé, Sujet âgé de 80 ans ou plus.
- MESH :
- diagnostic : Infections à coronavirus.
- traitement médicamenteux : Infections à coronavirus.
- usage thérapeutique : Antiviraux, Interféron alpha, Polyéthylène glycols, Protéines recombinantes, Ribavirine.
- virologie : Insuffisance respiratoire, Pneumopathie infectieuse.
- épidémiologie : Arabie saoudite.
- Adolescent, Adulte d'âge moyen, Association de médicaments, Centres de soins tertiaires, Coronavirus du syndrome respiratoire du Moyen-Orient, Délai jusqu'au traitement, Femelle, Humains, Infections asymptomatiques, Mâle, Retard de diagnostic, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adolescent, Aged, Aged, 80 and over, Antiviral Agents (therapeutic use), Asymptomatic Infections, Coronavirus Infections (diagnosis), Coronavirus Infections (drug therapy), Delayed Diagnosis, Drug Therapy, Combination, Female, Humans, Interferon alpha-2, Interferon-alpha (therapeutic use), Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus, Pneumonia (virology), Polyethylene Glycols (therapeutic use), Recombinant Proteins (therapeutic use), Respiratory Insufficiency (virology), Ribavirin (therapeutic use), Saudi Arabia (epidemiology), Tertiary Care Centers, Time-to-Treatment.
- MESH :
- chemical , therapeutic use : Antiviral Agents, Interferon-alpha, Polyethylene Glycols, Recombinant Proteins, Ribavirin.
- diagnosis : Coronavirus Infections.
- drug therapy : Coronavirus Infections.
- epidemiology : Saudi Arabia.
- virology : Pneumonia, Respiratory Insufficiency.
- Adolescent, Aged, Aged, 80 and over, Asymptomatic Infections, Delayed Diagnosis, Drug Therapy, Combination, Female, Humans, Interferon alpha-2, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus, Tertiary Care Centers, Time-to-Treatment.
Abstract
Middle Eastern respiratory syndrome caused by novel coronavirus (MERS CoV) has been a major public health challenge since it was first described in 2012 in Saudi Arabia. So far, there is no effective treatment for this serious illness, which features a high mortality rate. We report an initial experience of the use of ribavirin and interferon (IFN)-α2b in the management of MERS CoV at a tertiary care hospital.
A case series of 6 patients admitted with a confirmed diagnosis of MERS CoV were treated with ribavirin and IFN-α2b in addition to supportive management. The patients’ demographics, clinical parameters, and outcomes were recorded. Fifty-four close contacts of these patients were screened for MERS CoV.
Six patients with MERS CoV infection were included in this study. Four cases featured symptomatic disease, including pneumonia and respiratory failure, while 2 were asymptomatic close contacts of the MERS CoV patients. The MERS CoV infection was confirmed by reverse transcription–polymerase chain reaction detection of the consensus viral RNA targets upstream of the E gene (UPE) and open reading frame (ORF1b) on a sputum sample. The patients’ demographics, comorbid conditions, time to diagnosis and initiation of treatment, and clinical outcomes were recorded.
Three out of 6 patients who had comorbid conditions died during the study period, while 3 had successful outcomes. The diagnosis and treatment was delayed by an average of 15 days in those patients who died. Only 2 close contacts out of the 54 screened (3.7%) were positive for MERS CoV.
Treatment with ribavirin and IFN-α2b may be effective in patients infected with MERS CoV. There appears to be a low infectivity rate among close contacts of MERS CoV patients.
Url:
DOI: 10.5144/0256-4947.2014.396
PubMed: 25827696
PubMed Central: 6074560
Affiliations:
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Le document en format XML
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type="main">Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia</title><author><name sortKey="Khalid, Mohammad" sort="Khalid, Mohammad" uniqKey="Khalid M" first="Mohammad" last="Khalid">Mohammad Khalid</name></author><author><name sortKey="Khan, Basha" sort="Khan, Basha" uniqKey="Khan B" first="Basha" last="Khan">Basha Khan</name></author><author><name sortKey="Al Rabiah, Fahad" sort="Al Rabiah, Fahad" uniqKey="Al Rabiah F" first="Fahad" last="Al Rabiah">Fahad Al Rabiah</name></author><author><name sortKey="Alismaili, Ruwaida" sort="Alismaili, Ruwaida" uniqKey="Alismaili R" first="Ruwaida" last="Alismaili">Ruwaida Alismaili</name></author><author><name sortKey="Saleemi, Sarfraz" sort="Saleemi, Sarfraz" uniqKey="Saleemi S" first="Sarfraz" last="Saleemi">Sarfraz Saleemi</name></author><author><name sortKey="Rehan Khaliq, Agha Muhammad" sort="Rehan Khaliq, Agha Muhammad" uniqKey="Rehan Khaliq A" first="Agha Muhammad" last="Rehan-Khaliq">Agha Muhammad Rehan-Khaliq</name></author><author><name sortKey="Weheba, Ihab" sort="Weheba, Ihab" uniqKey="Weheba I" first="Ihab" last="Weheba">Ihab Weheba</name></author><author><name sortKey="Al Abdely, Hail" sort="Al Abdely, Hail" uniqKey="Al Abdely H" first="Hail" last="Al Abdely">Hail Al Abdely</name></author><author><name sortKey="Halim, Magid" sort="Halim, Magid" uniqKey="Halim M" first="Magid" last="Halim">Magid Halim</name></author><author><name sortKey="Nadri, Quaid Johar" sort="Nadri, Quaid Johar" uniqKey="Nadri Q" first="Quaid Johar" last="Nadri">Quaid Johar Nadri</name></author><author><name sortKey="Al Dalaan, Abdullah Mohsin" sort="Al Dalaan, Abdullah Mohsin" uniqKey="Al Dalaan A" first="Abdullah Mohsin" last="Al Dalaan">Abdullah Mohsin Al Dalaan</name></author><author><name sortKey="Zeitouni, Mohamed" sort="Zeitouni, Mohamed" uniqKey="Zeitouni M" first="Mohamed" last="Zeitouni">Mohamed Zeitouni</name></author><author><name sortKey="Butt, Taimur" sort="Butt, Taimur" uniqKey="Butt T" first="Taimur" last="Butt">Taimur Butt</name></author><author><name sortKey="Al Mutairy, Eid" sort="Al Mutairy, Eid" uniqKey="Al Mutairy E" first="Eid" last="Al Mutairy">Eid Al Mutairy</name></author></analytic><series><title level="j">Annals of Saudi Medicine</title><idno type="ISSN">0256-4947</idno><idno type="eISSN">0975-4466</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Aged</term><term>Aged, 80 and over</term><term>Antiviral Agents (therapeutic use)</term><term>Asymptomatic Infections</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (drug therapy)</term><term>Delayed Diagnosis</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Interferon alpha-2</term><term>Interferon-alpha (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Pneumonia (virology)</term><term>Polyethylene Glycols (therapeutic use)</term><term>Recombinant Proteins (therapeutic use)</term><term>Respiratory Insufficiency (virology)</term><term>Ribavirin (therapeutic use)</term><term>Saudi Arabia (epidemiology)</term><term>Tertiary Care Centers</term><term>Time-to-Treatment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte d'âge moyen</term><term>Antiviraux (usage thérapeutique)</term><term>Arabie saoudite (épidémiologie)</term><term>Association de médicaments</term><term>Centres de soins tertiaires</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Délai jusqu'au traitement</term><term>Femelle</term><term>Humains</term><term>Infections asymptomatiques</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Insuffisance respiratoire (virologie)</term><term>Interféron alpha (usage thérapeutique)</term><term>Mâle</term><term>Pneumopathie infectieuse (virologie)</term><term>Polyéthylène glycols (usage thérapeutique)</term><term>Protéines recombinantes (usage thérapeutique)</term><term>Retard de diagnostic</term><term>Ribavirine (usage thérapeutique)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Interferon-alpha</term><term>Polyethylene Glycols</term><term>Recombinant Proteins</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Interféron alpha</term><term>Polyéthylène glycols</term><term>Protéines recombinantes</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Insuffisance respiratoire</term><term>Pneumopathie infectieuse</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Pneumonia</term><term>Respiratory Insufficiency</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Arabie saoudite</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Aged</term><term>Aged, 80 and over</term><term>Asymptomatic Infections</term><term>Delayed Diagnosis</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Interferon alpha-2</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Tertiary Care Centers</term><term>Time-to-Treatment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Centres de soins tertiaires</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Délai jusqu'au traitement</term><term>Femelle</term><term>Humains</term><term>Infections asymptomatiques</term><term>Mâle</term><term>Retard de diagnostic</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>BACKGROUND AND OBJECTIVES</title><p>Middle Eastern respiratory syndrome caused by novel coronavirus (MERS CoV) has been a major public health challenge since it was first described in 2012 in Saudi Arabia. So far, there is no effective treatment for this serious illness, which features a high mortality rate. We report an initial experience of the use of ribavirin and interferon (IFN)-α2b in the management of MERS CoV at a tertiary care hospital.</p></sec><sec><title>DESIGN AND SETTINGS</title><p>A case series of 6 patients admitted with a confirmed diagnosis of MERS CoV were treated with ribavirin and IFN-α2b in addition to supportive management. The patients’ demographics, clinical parameters, and outcomes were recorded. Fifty-four close contacts of these patients were screened for MERS CoV.</p></sec><sec><title>METHODS</title><p>Six patients with MERS CoV infection were included in this study. Four cases featured symptomatic disease, including pneumonia and respiratory failure, while 2 were asymptomatic close contacts of the MERS CoV patients. The MERS CoV infection was confirmed by reverse transcription–polymerase chain reaction detection of the consensus viral RNA targets upstream of the E gene (UPE) and open reading frame (ORF1b) on a sputum sample. The patients’ demographics, comorbid conditions, time to diagnosis and initiation of treatment, and clinical outcomes were recorded.</p></sec><sec><title>RESULTS</title><p>Three out of 6 patients who had comorbid conditions died during the study period, while 3 had successful outcomes. The diagnosis and treatment was delayed by an average of 15 days in those patients who died. Only 2 close contacts out of the 54 screened (3.7%) were positive for MERS CoV.</p></sec><sec><title>CONCLUSION</title><p>Treatment with ribavirin and IFN-α2b may be effective in patients infected with MERS CoV. There appears to be a low infectivity rate among close contacts of MERS CoV patients.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C Martellaro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, K" uniqKey="Khan K">K Khan</name></author><author><name sortKey="Sears, J" uniqKey="Sears J">J Sears</name></author><author><name sortKey="Hu, Vw" uniqKey="Hu V">VW Hu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alagaili, An" uniqKey="Alagaili A">AN Alagaili</name></author><author><name sortKey="Briese, T" uniqKey="Briese T">T Briese</name></author><author><name sortKey="Mishra, N" uniqKey="Mishra N">N Mishra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saey, Th" uniqKey="Saey T">TH Saey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Briese, T" uniqKey="Briese T">T Briese</name></author><author><name sortKey="Mishra, N" uniqKey="Mishra N">N Mishra</name></author><author><name sortKey="Jain, K" uniqKey="Jain K">K Jain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name></author><author><name sortKey="El Kafrawy, Sa" uniqKey="El Kafrawy S">SA El-Kafrawy</name></author><author><name sortKey="Farraj, Sa" uniqKey="Farraj S">SA Farraj</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Momattin, H" uniqKey="Momattin H">H Momattin</name></author><author><name sortKey="Dib, J" uniqKey="Dib J">J Dib</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author><author><name sortKey="Saad, Mm" uniqKey="Saad M">MM Saad</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K Baig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guery, B" uniqKey="Guery B">B Guery</name></author><author><name sortKey="Van Der Werf, S" uniqKey="Van Der Werf S">S van der Werf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C Martellaro</name></author><author><name sortKey="Callison, J" uniqKey="Callison J">J Callison</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Momattin, H" uniqKey="Momattin H">H Momattin</name></author><author><name sortKey="Mohammed, K" uniqKey="Mohammed K">K Mohammed</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Al Abdely, Hail" sort="Al Abdely, Hail" uniqKey="Al Abdely H" first="Hail" last="Al Abdely">Hail Al Abdely</name><name sortKey="Al Dalaan, Abdullah Mohsin" sort="Al Dalaan, Abdullah Mohsin" uniqKey="Al Dalaan A" first="Abdullah Mohsin" last="Al Dalaan">Abdullah Mohsin Al Dalaan</name><name sortKey="Al Mutairy, Eid" sort="Al Mutairy, Eid" uniqKey="Al Mutairy E" first="Eid" last="Al Mutairy">Eid Al Mutairy</name><name sortKey="Al Rabiah, Fahad" sort="Al Rabiah, Fahad" uniqKey="Al Rabiah F" first="Fahad" last="Al Rabiah">Fahad Al Rabiah</name><name sortKey="Alismaili, Ruwaida" sort="Alismaili, Ruwaida" uniqKey="Alismaili R" first="Ruwaida" last="Alismaili">Ruwaida Alismaili</name><name sortKey="Butt, Taimur" sort="Butt, Taimur" uniqKey="Butt T" first="Taimur" last="Butt">Taimur Butt</name><name sortKey="Halim, Magid" sort="Halim, Magid" uniqKey="Halim M" first="Magid" last="Halim">Magid Halim</name><name sortKey="Khalid, Mohammad" sort="Khalid, Mohammad" uniqKey="Khalid M" first="Mohammad" last="Khalid">Mohammad Khalid</name><name sortKey="Khan, Basha" sort="Khan, Basha" uniqKey="Khan B" first="Basha" last="Khan">Basha Khan</name><name sortKey="Nadri, Quaid Johar" sort="Nadri, Quaid Johar" uniqKey="Nadri Q" first="Quaid Johar" last="Nadri">Quaid Johar Nadri</name><name sortKey="Rehan Khaliq, Agha Muhammad" sort="Rehan Khaliq, Agha Muhammad" uniqKey="Rehan Khaliq A" first="Agha Muhammad" last="Rehan-Khaliq">Agha Muhammad Rehan-Khaliq</name><name sortKey="Saleemi, Sarfraz" sort="Saleemi, Sarfraz" uniqKey="Saleemi S" first="Sarfraz" last="Saleemi">Sarfraz Saleemi</name><name sortKey="Weheba, Ihab" sort="Weheba, Ihab" uniqKey="Weheba I" first="Ihab" last="Weheba">Ihab Weheba</name><name sortKey="Zeitouni, Mohamed" sort="Zeitouni, Mohamed" uniqKey="Zeitouni M" first="Mohamed" last="Zeitouni">Mohamed Zeitouni</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|clé= PMC:6074560
|texte= Middle Eastern Respiratory Syndrome Corona Virus (MERS CoV): case reports from a tertiary care hospital in Saudi Arabia
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25827696" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidV1
| This area was generated with Dilib version V0.6.33. |  |